Comparison of Biomarker Assays for EGFR : Implications for Precision Medicine in Patients with Glioblastoma

Abstract excerpt

Abstract Purpose: Patients with glioblastoma (GBM) have a poor prognosis and are in desperate need of better therapies. As therapeutic decisions are increasingly guided by biomarkers, and EGFR abnormalities are common in GBM, thus representing a potential therapeutic target, we systematically evaluated methods of assessing EGFR amplification by multiple assays. Specifically, we evaluated correlation among...

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