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Article

Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2006

Sok John C, Coppelli Francesca M, Thomas Sufi M, Lango Miriam N, Xi Sichuan, Hunt Jennifer L, Freilino Maria L, Graner Michael W, Wikstrand Carol J, Bigner Darell D, Gooding William E, Furnari Frank B, Grandis Jennifer R

Abstract excerpt

PURPOSE: Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous cell carcinoma (HNSCC) where expression levels correlate with decreased survival. Therapies that block EGFR have shown limited efficacy in clinical trials and primarily when combined with standard therapy. The most common form of mutant EGFR (EGFRvIII) has been described in several cancers, chiefly glioblastoma. The...

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Source

Identifiers

PMID: 16951222
DOI: 10.1158/1078-0432.CCR-06-0913

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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