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Article

Genetic Alterations of Epidermal Growth Factor Receptor in Glioblastoma: The Usefulness of Immunohistochemistry.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Sept 2019

Lee Minju, Kang So Young, Suh Yeon-Lim

Abstract excerpt

Epidermal growth factor receptor (EGFR) amplification is one of the common alterations in IDH-wildtype glioblastoma. It is frequently associated with EGFRvIII mutation. To evaluate the correlation between EGFR overexpression, gene amplification, and EGFRvIII mutation, we performed immunohistochemical (IHC) analysis, fluorescence in situ hybridization by Vysis LSI EGFR/CEP7 dual color probe, and polymerase chain...

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Identifiers

PMID: 29912767
DOI: 10.1097/PAI.0000000000000669

Genes

EGFR

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