Article
Mapping of genomic EGFRvIII deletions in glioblastoma: insight into rearrangement mechanisms and biomarker development.
Neuro-oncology - 3 Sept 2018
Koga Tomoyuki, Li Bin, Figueroa Javier M, Ren Bing, Chen Clark C, Carter Bob S, Furnari Frank B
Abstract excerpt
Background: Epidermal growth factor receptor (EGFR) variant III (vIII) is the most common oncogenic rearrangement in glioblastoma (GBM), generated by deletion of exons 2 to 7 of EGFR. The proximal breakpoints occur in variable positions within the 123-kb intron 1, presenting significant challenges in terms of polymerase chain reaction (PCR)-based mapping. Molecular mechanisms underlying these deletions remain...
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