Assessment and prognostic significance of the epidermal growth factor receptor vIII mutation in glioblastoma patients treated with concurrent and adjuvant temozolomide radiochemotherapy.

doi:10.1002/ijc.28576

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Article

Assessment and prognostic significance of the epidermal growth factor receptor vIII mutation in glioblastoma patients treated with concurrent and adjuvant temozolomide radiochemotherapy.

International journal of cancer - 15 May 2014

Weller Michael, Kaulich Kerstin, Hentschel Bettina, Felsberg Joerg, Gramatzki Dorothee, Pietsch Torsten, Simon Matthias, Westphal Manfred, Schackert Gabriele, Tonn Joerg C, von Deimling Andreas, Davis Thomas, Weiss William Andrew, Loeffler Markus, Reifenberger Guido

Abstract excerpt

The epidermal growth factor receptor vIII mutant (EGFRvIII) is found in ~50% of all EGFR-amplified glioblastomas and constitutes a tumor-specific therapeutic target. To assess molecular testing approaches and the prognostic role of EGFRvIII in patients treated according to current standards of care, we compared different EGFRvIII detection methods and correlated EGFRvIII status with outcome in a prospective...

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PMID: 24614983
DOI: 10.1002/ijc.28576

Genes

EGFR
MGMT

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