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Article

Highly Sensitive EGFRvIII Detection in Circulating Extracellular Vesicle RNA of Glioma Patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2022

Batool Syeda Maheen, Muralidharan Koushik, Hsia Tiffany, Falotico Sarah, Gamblin Austin S, Rosenfeld Yulia B, Khanna Sirena K, Balaj Leonora, Carter Bob S

Abstract excerpt

PURPOSE: Liquid biopsy offers an attractive platform for noninvasive tumor diagnosis, prognostication, and prediction of glioblastoma clinical outcomes. Prior studies report that 30% to 50% of GBM lesions characterized by EGFR amplification also harbor the EGFRvIII mutation. EXPERIMENTAL DESIGN: A novel digital droplet PCR (ddPCR) assay for high GC content amplicons was developed and optimized for sensitive...

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Identifiers

PMID: 35849415
DOI: 10.1158/1078-0432.CCR-22-0444
PMCID: PMC9475243

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