Article
Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas.
Brain pathology (Zurich, Switzerland) - 1 Apr 2004
Biernat Wojciech, Huang Hervé, Yokoo Hideaki, Kleihues Paul, Ohgaki Hiroko
Abstract excerpt
EGFR amplification is a frequent genetic alteration in primary (de novo) glioblastomas, and is often associated with structural alterations. Most common is variant III (EGFRvIII), which results from a non-random 801 bp in-frame deletion of exons 2 to 7 of the EGFR gene. We assessed amplification and overexpression of EGFRvIII and wild-type EGFR in 30 glioblastoma biopsies. Immunohistochemically, EGFR...
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