Article
Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients.
Neuro-oncology - 19 Oct 2017
Figueroa Javier M, Skog Johan, Akers Johnny, Li Hongying, Komotar Ricardo, Jensen Randy, Ringel Florian, Yang Isaac, Kalkanis Steven, Thompson Reid, LoGuidice Lori, Berghoff Emily, Parsa Andrew, Liau Linda, Curry William, Cahill Daniel, Bettegowda Chetan, Lang Frederick F, Chiocca E Antonio, Henson John, Kim Ryan, Breakefield Xandra, Chen Clark, Messer Karen, Hochberg Fred, Carter Bob S
Abstract excerpt
BACKGROUND: RNAs within extracellular vesicles (EVs) have potential as diagnostic biomarkers for patients with cancer and are identified in a variety of biofluids. Glioblastomas (GBMs) release EVs containing RNA into cerebrospinal fluid (CSF). Here we describe a multi-institutional study of RNA extracted from CSF-derived EVs of GBM patients to detect the presence of tumor-associated amplifications and mutations...
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