Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in EGFR-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors.

doi:10.1158/1078-0432.CCR-17-0890

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Article

Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in EGFR-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2017

Felsberg Jörg, Hentschel Bettina, Kaulich Kerstin, Gramatzki Dorothee, Zacher Angela, Malzkorn Bastian, Kamp Marcel, Sabel Michael, Simon Matthias, Westphal Manfred, Schackert Gabriele, Tonn Jörg C, Pietsch Torsten, von Deimling Andreas, Loeffler Markus, Reifenberger Guido, Weller Michael

Abstract excerpt

Purpose: Approximately 40% of all glioblastomas have amplified the EGFR gene, and about half of these tumors express the EGFRvIII variant. The prognostic role of EGFRvIII in EGFR-amplified glioblastoma patients and changes in EGFRvIII expression in recurrent versus primary glioblastomas remain controversial, but such data are highly relevant for EGFRvIII-targeted therapies.Experimental Design:EGFR-amplified...

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PMID: 28855349
DOI: 10.1158/1078-0432.CCR-17-0890

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