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Article

Distinct mechanisms of calmodulin binding and regulation of adenylyl cyclases 1 and 8.

Biochemistry - 9 Oct 2012

Masada Nanako, Schaks Sabine, Jackson Sophie E, Sinz Andrea, Cooper Dermot M F

Abstract excerpt

Calmodulin (CaM), by mediating the stimulation of the activity of two adenylyl cyclases (ACs), plays a key role in integrating the cAMP and Ca(2+) signaling systems. These ACs, AC1 and AC8, by decoding discrete Ca(2+) signals can contribute to fine-tuning intracellular cAMP dynamics, particularly in neurons where they predominate. CaM comprises an α-helical linker separating two globular regions at the N-terminus...

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Identifiers

PMID: 22971080
DOI: 10.1021/bi300646y
PMCID: PMC3466776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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