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Article

Identification of a Gialpha binding site on type V adenylyl cyclase.

The Journal of biological chemistry - 2 Oct 1998

Dessauer C W, Tesmer J J, Sprang S R, Gilman A G

Abstract excerpt

The stimulatory G protein alpha subunit Gsalpha binds within a cleft in adenylyl cyclase formed by the alpha1-alpha2 and alpha3-beta4 loops of the C2 domain. The pseudosymmetry of the C1 and C2 domains of adenylyl cyclase suggests that the homologous inhibitory alpha subunit Gialpha could bind to the analogous cleft within C1. We demonstrate that myristoylated guanosine 5'-3-O-(thio)triphosphate-Gialpha1 forms a...

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PMID: 9748257
DOI: 10.1074/jbc.273.40.25831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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