Article
Identification of a Gialpha binding site on type V adenylyl cyclase.
The Journal of biological chemistry - 2 Oct 1998
Dessauer C W, Tesmer J J, Sprang S R, Gilman A G
Abstract excerpt
The stimulatory G protein alpha subunit Gsalpha binds within a cleft in adenylyl cyclase formed by the alpha1-alpha2 and alpha3-beta4 loops of the C2 domain. The pseudosymmetry of the C1 and C2 domains of adenylyl cyclase suggests that the homologous inhibitory alpha subunit Gialpha could bind to...
Topics
- Adenylyl Cyclases
- Amino Acid Sequence
- Animals
- Baculoviridae
- Binding Sites
- Dogs
- Enzyme Inhibitors
- GTP-Binding Proteins
- Guanosine Triphosphate
- Mice
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Protein Binding
- Sequence Alignment
- Ultracentrifugation