Article
Mutations uncover a role for two magnesium ions in the catalytic mechanism of adenylyl cyclase.
The Journal of biological chemistry - 31 Jul 1998
Zimmermann G, Zhou D, Taussig R
Abstract excerpt
The recent determination of the crystal structure of adenylyl cyclase has elucidated many structural features that determine the regulatory properties of the enzyme. In addition, the characterization of adenylyl cyclase by mutagenic techniques and the identification of the binding site for P-site...
Topics
- Adenosine Triphosphate
- Adenylyl Cyclases
- Animals
- Baculoviridae
- Catalysis
- Cells, Cultured
- GTP-Binding Proteins
- Gene Expression
- Gene Expression Regulation, Enzymologic
- Magnesium
- Mammals
- Manganese
- Models, Molecular
- Mutation
- Saccharomyces cerevisiae
- Spodoptera