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Article

Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension.

JAMA - 23 Jan 2008

Lynch Amy I, Boerwinkle Eric, Davis Barry R, Ford Charles E, Eckfeldt John H, Leiendecker-Foster Catherine, Arnett Donna K

Abstract excerpt

CONTEXT: The NPPA gene codes for the precursor of atrial natriuretic polypeptide, suggesting that NPPA may modulate the efficacy of some antihypertensive drugs. OBJECTIVE: To test whether participants with minor NPPA alleles in the T2238C or G664A variants had different rates of cardiovascular disease or blood pressure (BP) changes than common allele homozygotes when treated with a diuretic vs other...

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Source

Identifiers

PMID: 18212314
DOI: 10.1001/jama.299.3.296

Genes

NPPA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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