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Article

Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure.

Nature genetics - 1 Mar 2009

Newton-Cheh Christopher, Larson Martin G, Vasan Ramachandran S, Levy Daniel, Bloch Kenneth D, Surti Aarti, Guiducci Candace, Kathiresan Sekar, Benjamin Emelia J, Struck Joachim, Morgenthaler Nils G, Bergmann Andreas, Blankenberg Stefan, Kee Frank, Nilsson Peter, Yin Xiaoyan, Peltonen Leena, Vartiainen Erkki, Salomaa Veikko, Hirschhorn Joel N, Melander Olle, Wang Thomas J

Abstract excerpt

We examined the association of common variants at the NPPA-NPPB locus with circulating concentrations of the natriuretic peptides, which have blood pressure-lowering properties. We genotyped SNPs at the NPPA-NPPB locus in 14,743 individuals of European ancestry, and identified associations of plasma atrial natriuretic peptide with rs5068 (P = 8 x 10(-70)), rs198358 (P = 8 x 10(-30)) and rs632793 (P = 2 x...

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Source

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Identifiers

PMID: 19219041
DOI: 10.1038/ng.328
PMCID: PMC2664511

Genes

NPPA
NPPB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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