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Article

Antihypertensive pharmacogenetic effect of fibrinogen-beta variant -455G>A on cardiovascular disease, end-stage renal disease, and mortality: the GenHAT study.

Pharmacogenetics and genomics - 1 Jun 2009

Lynch Amy I, Boerwinkle Eric, Davis Barry R, Ford Charles E, Eckfeldt John H, Leiendecker-Foster Catherine, Arnett Donna K

Abstract excerpt

OBJECTIVE: The FGB gene codes for fibrinogen-beta, a polypeptide of the coagulation factor fibrinogen, which is positively associated with cardiovascular diseases. Studies show that angiotensin-converting enzyme (ACE) inhibitors lower plasma fibrinogen concentrations, whereas diuretics and calcium-channel blockers do not. As carriers of the FGB-455 minor 'A' allele have higher levels of fibrinogen while ACE...

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Source

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Identifiers

PMID: 19352213
DOI: 10.1097/FPC.0b013e32832a8e81
PMCID: PMC2764310

Genes

FGB
ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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