A pharmacogenetic analysis of determinants of hypertension and blood pressure response to angiotensin-converting enzyme inhibitor therapy in patients with vascular disease and healthy individuals.

doi:10.1097/HJH.0b013e328341d117

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Article

A pharmacogenetic analysis of determinants of hypertension and blood pressure response to angiotensin-converting enzyme inhibitor therapy in patients with vascular disease and healthy individuals.

Journal of hypertension - 1 Mar 2011

Brugts Jasper J, Isaacs Aaron, de Maat Moniek Pm, Boersma Eric, van Duijn Cock M, Akkerhuis K Martijn, Uitterlinden Andre G, Witteman Jacqueline Cm, Cambien Francois, Ceconi Claudio, Remme Willem, Bertrand Michel, Ninomiya Toshiharu, Harrap Stephen, Chalmers John, Macmahon Stephen, Fox Kim, Ferrari Roberto, Simoons Maarten L, Danser Ah Jan

Abstract excerpt

AIMS: To investigate whether genetic variation in the renin-angiotensin-aldosterone system (RAAS) and kallikrein-bradykinin pathways is related to hypertension and blood pressure (BP) response to angiotensin-converting enzyme (ACE) inhibitor therapy in stable coronary artery disease (CAD) patients. METHODS AND RESULTS: In 8907 stable CAD patients from the EUROPA trial, 52 haplotype-tagging single-nucleotide...

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PMID: 21157371
DOI: 10.1097/HJH.0b013e328341d117

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