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Article

Pharmacogenetic associations of MMP9 and MMP12 variants with cardiovascular disease in patients with hypertension.

PloS one - 1 Jan 2011

Tanner Rikki M, Lynch Amy I, Brophy Victoria H, Eckfeldt John H, Davis Barry R, Ford Charles E, Boerwinkle Eric, Arnett Donna K

Abstract excerpt

OBJECTIVES: MMP-9 and -12 function in tissue remodeling and may play roles in cardiovascular disease (CVD). We assessed associations of four MMP polymorphisms and three antihypertensive drugs with cardiovascular outcomes. METHODS: Hypertensives (n = 42,418) from a double-blind, randomized, clinical trial were randomized to chlorthalidone, amlodipine, lisinopril, or doxazosin treatment (mean follow up, 4.9 years)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 21887284
DOI: 10.1371/journal.pone.0023609
PMCID: PMC3160956

Genes

MMP12
MMP9

Variants

rs652438
rs17576
rs2274756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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