Article
Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study.
Circulation - 28 Jun 2005
Arnett Donna K, Davis Barry R, Ford Charles E, Boerwinkle Eric, Leiendecker-Foster Cathie, Miller Michael B, Black Henry, Eckfeldt John H
Abstract excerpt
BACKGROUND: Previous studies have reported that blood pressure response to antihypertensive medications is influenced by genetic variation in the renin-angiotensin-aldosterone system, but no clinical trails have tested whether the ACE insertion/deletion (I/D) polymorphism modifies the association between the type of medication and multiple cardiovascular and renal phenotypes. METHODS AND RESULTS: We used a...
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