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Article

Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study.

PloS one - 1 Jan 2012

Zhang Xue, Lynch Amy I, Davis Barry R, Ford Charles E, Boerwinkle Eric, Eckfeldt John H, Leiendecker-Foster Catherine, Arnett Donna K

Abstract excerpt

Nitric oxide synthase 3 (NOS3) catalyzes production of NO in the endothelium and may play a role in cardiovascular disease (CVD). We assessed the pharmacogenetic associations of three NOS3 polymorphisms and three antihypertensive drugs with CVD outcomes. Hypertensive subjects (n = 30,280) from a multi-center, double-blind clinical trial were randomized to chlorthalidone, amlodipine, or lisinopril treatment (mean...

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Identifiers

PMID: 22470539
DOI: 10.1371/journal.pone.0034217
PMCID: PMC3314599

Genes

NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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