Article
Pharmacogenetic implications for eight common blood pressure-associated single-nucleotide polymorphisms.
Journal of hypertension - 1 Jun 2012
Hamrefors Viktor, Sjögren Marketa, Almgren Peter, Wahlstrand Björn, Kjeldsen Sverre, Hedner Thomas, Melander Olle
Abstract excerpt
OBJECTIVE: We aimed to test whether eight common recently identified single-nucleotide polymorphisms (SNPs), strongly associated with blood pressure (BP) in the population, also have impact on the degree of BP reduction by antihypertensive agents with different mechanisms. METHODS: In 3863 Swedish hypertensive patients, we related number of unfavorable alleles of each SNP (i.e. alleles associated with higher...
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