Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The origin recognition complex is dispensable for endoreplication in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America - 26 Aug 2008

Park So Young, Asano Maki

Abstract excerpt

The origin recognition complex (ORC) is an essential component of the prereplication complex (pre-RC) in mitotic cell cycles. The role of ORC as a foundation to assemble the pre-RC is conserved from yeast to human. Furthermore, in metazoans ORC plays a key role in determining the timing of replication initiation and origin usage. In this report we have produced and analyzed a Drosophila orc1 allele to investigate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Cycle Proteins
Share to DNA Replication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila

Share to Drosophila Proteins

Share to Mitosis

Share to Origin Recognition Complex

Share to Salivary Glands

Source

Open in PubMed Open full text

Identifiers

PMID: 18711130
DOI: 10.1073/pnas.0805189105
PMCID: PMC2527913

Genes

ORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The origin recognition complex is dispensable for endoreplication in Drosophila.PMID 18711130Read ↗

An orc1 allele with a mutated APC motif is female sterile with amplification defects.Semantic proximity Read ↗

A Meier-Gorlin Syndrome Mutation in Orc4 Causes Tissue-Specific DNA Replication Defects in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

Tissue-Specific DNA Replication Defects in Drosophila melanogaster Caused by a Meier-Gorlin Syndrome Mutation in Orc4.Semantic proximity Read ↗

Orc mutants arrest in metaphase with abnormally condensed chromosomes.Semantic proximity Read ↗

Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome.Semantic proximity Read ↗

The cyclin-dependent kinase inhibitor Dacapo promotes replication licensing during Drosophila endocycles.Semantic proximity Read ↗

The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.Semantic proximity Read ↗

The human Origin Recognition Complex is essential for pre-RC assembly, mitosis and maintenance of nuclear structureSemantic proximity Read ↗

CAF-1 is required for efficient replication of euchromatic DNA in Drosophila larval endocycling cells.Semantic proximity Read ↗

Functional analysis of an Orc6 mutant in Drosophila.Semantic proximity Read ↗

Mammalian endoreplication emerges to reveal a potential developmental timerSemantic proximity Read ↗

A WD-repeat protein stabilizes ORC binding to chromatin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.