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Article

Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2006

Gibson Daniel G, Bell Stephen P, Aparicio Oscar M

Abstract excerpt

Chromosomal replication initiates through the assembly of a prereplicative complex (pre-RC) at individual replication origins in the G1-phase, followed by activation of these complexes in the S-phase. In Saccharomyces cerevisiae, the origin recognition complex (ORC) binds replication origins throughout the cell cycle and participates in pre-RC assembly. Whether the ORC plays an additional role subsequent to...

Topics

Alleles
Cell Cycle
Cell Cycle Proteins
Checkpoint Kinase 2
DNA Damage
DNA, Fungal
Gene Silencing
Mitosis
Mutation
Origin Recognition Complex
Protein Serine-Threonine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Subunits

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Spindle Apparatus

Source

Identifiers

PMID: 16716188
DOI: 10.1111/j.1365-2443.2006.00967.x

Genes

ORC1
ORC2
ORC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae.PMID 16716188Read ↗

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The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.Semantic proximity Read ↗

Analysis of origin recognition complex in saccharomyces cerevisiae by use of Degron mutants.Semantic proximity Read ↗

Schizosaccharomyces pombe Orc5 plays multiple roles in the maintenance of genome stability throughout the cell cycle.Semantic proximity Read ↗

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ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase.Semantic proximity Read ↗

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