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Article

Orc mutants arrest in metaphase with abnormally condensed chromosomes.

Development (Cambridge, England) - 1 May 2001

Pflumm M F, Botchan M R

Abstract excerpt

The origin recognition complex (ORC) is a six subunit complex required for eukaryotic DNA replication initiation and for silencing of the heterochromatic mating type loci in Saccharomyces cerevisiae. Our discovery of the Drosophila ORC complex concentrated in the centric heterochromatin of mitotic cells in the early embryo and its interactions with heterochromatin protein 1 (HP-1) lead us to speculate that ORC...

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Source

Identifiers

PMID: 11290306
DOI: 10.1242/dev.128.9.1697

Genes

MCM4
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Orc mutants arrest in metaphase with abnormally condensed chromosomes.PMID 11290306Read ↗

Aberrant replication timing induces defective chromosome condensation in Drosophila ORC2 mutants.Semantic proximity Read ↗

Schizosaccharomyces pombe Orc5 plays multiple roles in the maintenance of genome stability throughout the cell cycle.Semantic proximity Read ↗

The origin recognition complex is dispensable for endoreplication in Drosophila.Semantic proximity Read ↗

Functional analysis of an Orc6 mutant in Drosophila.Semantic proximity Read ↗

Orc6 involved in DNA replication, chromosome segregation, and cytokinesis.Semantic proximity Read ↗

Drosophila heterochromatin protein 1 (HP1)/origin recognition complex (ORC) protein is associated with HP1 and ORC and functions in heterochromatin-induced silencing.Semantic proximity Read ↗

Roles for ORC in M phase and S phase.Semantic proximity Read ↗

Mutations in the Drosophila condensin subunit dCAP-G: defining the role of condensin for chromosome condensation in mitosis and gene expression in interphase.Semantic proximity Read ↗

A WD-repeat protein stabilizes ORC binding to chromatin.Semantic proximity Read ↗

The role of DNA replication in chromosome condensation.Semantic proximity Read ↗

Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase.Semantic proximity Read ↗

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