Article
TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Sept 2008
Meissner Rose-Anne, Kilman Valerie L, Lin Jui-Ming, Allada Ravi
Abstract excerpt
Circadian oscillations in clock components are central to generation of self-sustained 24-h periodicity. In the Drosophila molecular clock, accumulation, phosphorylation, and degradation of PERIOD (PER) and TIMELESS (TIM) proteins govern period length. Yet little is known about the kinases that p...
Topics
- Animals
- Animals, Genetically Modified
- Casein Kinase II
- Circadian Rhythm
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation
- Mutation
- Neurons
- Nuclear Proteins
- Period Circadian Proteins
- Phosphorylation
- Serine
- Time Factors