A role for CK2 in the Drosophila circadian oscillator.

doi:10.1038/nn1007

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Article

A role for CK2 in the Drosophila circadian oscillator.

Nature neuroscience - 1 Mar 2003

Akten Bikem, Jauch Eike, Genova Ginka K, Kim Eun Young, Edery Isaac, Raabe Thomas, Jackson F Rob

Abstract excerpt

The posttranslational modification of clock proteins is critical for the function of circadian oscillators. By genetic analysis of a Drosophila melanogaster circadian clock mutant known as Andante, which has abnormally long circadian periods, we show that casein kinase 2 (CK2) has a role in determining period length. Andante is a mutation of the gene encoding the beta subunit of CK2 and is predicted to perturb...

Topics

Active Transport, Cell Nucleus
Animals
Biological Clocks
Casein Kinase II
Circadian Rhythm
Dimerization
Drosophila Proteins
Drosophila melanogaster
Insect Proteins
Motor Activity
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurons

Nuclear Proteins

Period Circadian Proteins

Phenotype

Protein Binding

Protein Serine-Threonine Kinases

Protein Subunits

Source

Open in PubMed

Identifiers

PMID: 12563262
DOI: 10.1038/nn1007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12563262-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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