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Article

Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex.

Nature cell biology - 1 Feb 2008

Franch-Marro Xavier, Wendler Franz, Guidato Sonia, Griffith Janice, Baena-Lopez Alberto, Itasaki Nobue, Maurice Madelon M, Vincent Jean-Paul

Abstract excerpt

The glycolipoproteins of the Wnt family raise interesting trafficking issues, especially with respect to spreading within tissues. Recently, the retromer complex has been suggested to participate in packaging Wnts into long-range transport vehicles. Our analysis of a Drosophila mutant in Vps35 show that, instead, the retromer complex is required for efficient progression of Wingless (a Drosophila Wnt) through the...

Topics

Animals
Drosophila
Drosophila Proteins
Endosomes
Golgi Apparatus
Homeodomain Proteins
Intracellular Signaling Peptides and Proteins
Membrane Proteins
Mutation
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Transport

Proto-Oncogene Proteins

Transcription Factors

Vesicular Transport Proteins

Wnt1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 18193037
DOI: 10.1038/ncb1678
PMCID: PMC7611556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18193037-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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