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Article

SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless.

Cell research - 1 Dec 2011

Zhang Peng, Wu Yihui, Belenkaya Tatyana Y, Lin Xinhua

Abstract excerpt

Drosophila Wingless (Wg) acts as a morphogen during development. Wg secretion is controlled by a seven-pass transmembrane cargo Wntless (Wls). We have recently identified retromer as a key regulator involved in Wls trafficking. As sorting nexin (SNX) molecules are essential components of the retromer complex, we hypothesized that specific SNX(s) is required for retromer-mediated Wnt secretion. Here, we generated...

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Identifiers

PMID: 22041890
DOI: 10.1038/cr.2011.167
PMCID: PMC3357989

Genes

SNX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless.PMID 22041890Read ↗

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