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Article

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.

Nature communications - 13 Sept 2018

McGough Ian J, de Groot Reinoud E A, Jellett Adam P, Betist Marco C, Varandas Katherine C, Danson Chris M, Heesom Kate J, Korswagen Hendrik C, Cullen Peter J

Abstract excerpt

Wntless transports Wnt morphogens to the cell surface and is required for Wnt secretion and morphogenic gradients formation. Recycling of endocytosed Wntless requires the sorting nexin-3 (SNX3)-retromer-dependent endosome-to-Golgi transport pathway. Here we demonstrate the essential role of SNX3-retromer assembly for Wntless transport and report that SNX3 associates with an evolutionary conserved...

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Identifiers

PMID: 30213940
DOI: 10.1038/s41467-018-06114-3
PMCID: PMC6137200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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