Article
Glypicans shunt the Wingless signal between local signalling and further transport.
Development (Cambridge, England) - 1 Feb 2005
Franch-Marro Xavier, Marchand Oriane, Piddini Eugenia, Ricardo Sara, Alexandre Cyrille, Vincent Jean-Paul
Abstract excerpt
The two glypicans Dally and Dally-like have been implicated in modulating the activity of Wingless, a member of the Wnt family of secreted glycoprotein. So far, the lack of null mutants has prevented a rigorous assessment of their roles. We have created a small deletion in the two loci. Our analysis of single and double mutant embryos suggests that both glypicans participate in normal Wingless function, although...
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