Article
Wnt gradient formation requires retromer function in Wnt-producing cells.
Science (New York, N.Y.) - 12 May 2006
Coudreuse Damien Y M, Roël Giulietta, Betist Marco C, Destrée Olivier, Korswagen Hendrik C
Abstract excerpt
Wnt proteins function as morphogens that can form long-range concentration gradients to pattern developing tissues. Here, we show that the retromer, a multiprotein complex involved in intracellular protein trafficking, is required for long-range signaling of the Caenorhabditis elegans Wnt ortholog EGL-20. The retromer functions in EGL-20-producing cells to allow the formation of an EGL-20 gradient along the...
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