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Article

Roles of N-glycosylation and lipidation in Wg secretion and signaling.

Developmental biology - 1 Apr 2012

Tang Xiaofang, Wu Yihui, Belenkaya Tatyana Y, Huang Qinzhu, Ray Lorraine, Qu Jia, Lin Xinhua

Abstract excerpt

Wnt members act as morphogens essential for embryonic patterning and adult homeostasis. Currently, it is still unclear how Wnt secretion and its gradient formation are regulated. In this study, we examined the roles of N-glycosylation and lipidation/acylation in regulating the activities of Wingless (Wg), the main Drosophila Wnt member. We show that Wg mutant devoid of all the N-glycosylations exhibits no major...

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Identifiers

PMID: 22285813
DOI: 10.1016/j.ydbio.2012.01.009
PMCID: PMC3315154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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