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Article

Retromer disruption promotes amyloidogenic APP processing.

Neurobiology of disease - 1 Aug 2011

Sullivan Christopher P, Jay Anthony G, Stack Edward C, Pakaluk Maria, Wadlinger Erin, Fine Richard E, Wells John M, Morin Peter J

Abstract excerpt

Retromer deficiency has been implicated in sporadic AD and animals deficient in retromer components exhibit pronounced neurodegeneration. Because retromer performs retrograde transport from the endosome to the Golgi apparatus and neuronal Aβ is found in late endosomal compartments, we speculated that retromer malfunction might enhance amyloidogenic APP processing by promoting interactions between APP and...

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Source

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Identifiers

PMID: 21515373
DOI: 10.1016/j.nbd.2011.04.002
PMCID: PMC3114192

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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