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Article

Fez1/Lzts1-deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine (BBN) carcinogenesis.

Carcinogenesis - 1 Apr 2008

Baffa Raffaele, Fassan Matteo, Sevignani Cinzia, Vecchione Andrea, Ishii Hideshi, Giarnieri Enrico, Iozzo Renato V, Gomella Leonard G, Croce Carlo M

Abstract excerpt

FEZ1/LZTS1 is a tumor suppressor gene that is frequently altered in human cancers of different histotypes. We have reported previously that LZTS1 is downregulated in high-grade bladder cancer and that its restoration suppresses tumorigenicity in urothelial carcinoma cells. To further investigate the role of LZTS1 in the development of bladder cancer, we utilized heterozygous and nullizygous Lzts1 mice in a...

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Source

Identifiers

PMID: 18192690
DOI: 10.1093/carcin/bgn006

Genes

LZTS1
FEZ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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