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Article

Generation and functional characterization of mice with a disrupted glutathione S-transferase, theta 1 gene.

Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2007

Fujimoto Kazunori, Arakawa Shingo, Watanabe Toshiyuki, Yasumo Hiroaki, Ando Yosuke, Takasaki Wataru, Manabe Sunao, Yamoto Takashi, Oda Sen-Ichi

Abstract excerpt

Glutathione S-transferase (GST) theta 1 (GSTT1) has been regarded as one of the key enzymes involved in phase II reactions because of its unique substrate specificity. In this study, we generated mice with the disrupted Gstt1 gene (Gstt1-null mice) by gene targeting and analyzed the metabolic properties in cytosolic and in vivo studies. The resulting Gstt1-null mice failed to express the Gstt1 mRNA and GSTT1...

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Identifiers

PMID: 17827337
DOI: 10.1124/dmd.107.017905

Genes

GSTT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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