Article
Higher susceptibility to aflatoxin B(1)-related hepatocellular carcinoma in glycine N-methyltransferase knockout mice.
International journal of cancer - 1 Feb 2011
Liu Shih-Ping, Li Ying-Shiuan, Lee Cheng-Ming, Yen Chia-Hung, Liao Yi-Jen, Huang Shiu-Feng, Chien Chau-Heng, Chen Yi-Ming Arthur
Abstract excerpt
In both humans and rodents, males are known to be more susceptible than females to hepatocarcinogenesis. We have previously reported that glycine N-methyltransferase (GNMT) interacts with aflatoxin B(1) (AFB(1)) and reduces both AFB(1)-DNA adduct formation and hepatocellular carcinoma (HCC) in mice. We also reported that 50% of the males and 100% of the females in a small group of Gnmt null (Gnmt-/-) mice...
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