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Frequent p53 mutations and occasional loss of chromosome 4 in invasive bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in B6D2F1 mice.

Molecular carcinogenesis - 1 Jan 1998

Ogawa K, Uzvolgyi E, St John M K, de Oliveira M L, Arnold L, Cohen S M

Abstract excerpt

B6D2F1 mice (45/group) were treated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) or uracil as follows: Group 1 received 0.05% BBN in drinking water for the entire experiment, Group 2 received 5 mg of BBN by gastric gavage in 0.1 mL of 20% ethanol twice per week for 10 wk, Group 3 received a 2.5% uracil-containing diet for the entire experiment, and Group 4 was controls (received 0.1 ml of 20% ethanol by...

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Identifiers

PMID: 9473773
DOI: 10.1002/(sici)1098-2744(199801)21:1<70::aid-mc9>3.0.co;2-t

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