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Article

Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis.

Carcinogenesis - 1 Nov 2007

Iida Katsuyuki, Itoh Ken, Maher Jonathan M, Kumagai Yoshito, Oyasu Ryoichi, Mori Yukio, Shimazui Toru, Akaza Hideyuki, Yamamoto Masayuki

Abstract excerpt

Nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2), a transcription factor that regulates inducible expression of detoxifying enzymes, is critical in preventing N-nitrosobutyl(4-hydroxybutyl)amine (BBN)-induced urinary bladder carcinogenesis. To explore whether Nrf2 and the tumor suppressor p53 cooperatively act in tumor prevention, we investigated the susceptibility of Nrf2-/-::p53+/- mice to BBN-induced...

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Identifiers

PMID: 17602169
DOI: 10.1093/carcin/bgm146

Genes

NQO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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