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Article

Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis.

Cancer research - 15 Sept 2004

Iida Katsuyuki, Itoh Ken, Kumagai Yoshito, Oyasu Ryoichi, Hattori Kazunori, Kawai Koji, Shimazui Toru, Akaza Hideyuki, Yamamoto Masayuki

Abstract excerpt

The induction of phase 2 detoxifying enzymes, such as UDP-glucuronosyltransferases (UGTs), in response to an array of naturally occurring and synthetic agents, such as oltipraz (4-methyl-5-[2-pyrazinyl]-1,2-dithiole-3-thione), provides an effective means of protection against a variety of carcinogens. Transcription factor Nrf2 is an essential regulator of the inducible expression of detoxifying enzyme genes by...

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Identifiers

PMID: 15374950
DOI: 10.1158/0008-5472.CAN-04-1906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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