Article
Inactivation of the FHIT gene favors bladder cancer development.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2004
Vecchione Andrea, Sevignani Cinzia, Giarnieri Enrico, Zanesi Nicola, Ishii Hideshi, Cesari Rossano, Fong Louise Y Y, Gomella Leonard G, Croce Carlo M, Baffa Raffaele
Abstract excerpt
The fragile histidine triad (FHIT) gene located on chromosome 3p14.2 is frequently deleted in human tumors. We have previously reported deletions at the FHIT locus in 50% of bladder carcinoma derived cell lines and reduced expression in 61% of primary transitional carcinomas of the urinary bladder. To additionally investigate the role of FHIT alterations in the development of bladder cancer, we used heterozygous...
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