Article
Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo.
Cancer research - 15 Jun 2007
Aqeilan Rami I, Hagan John P, Aqeilan Haifa A, Pichiorri Flavia, Fong Louise Y Y, Croce Carlo M
Abstract excerpt
The WWOX gene encodes a tumor suppressor spanning the second most common human fragile site, FRA16D. Targeted deletion of the Wwox gene in mice led to an increased incidence of spontaneous and ethyl nitrosourea-induced tumors. In humans, loss of heterozygosity and reduced or loss of WWOX expression has been reported in esophageal squamous cell cancers (SCC). In the present study, we examined whether inactivation...
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