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Article

Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo.

Cancer research - 15 Jun 2007

Aqeilan Rami I, Hagan John P, Aqeilan Haifa A, Pichiorri Flavia, Fong Louise Y Y, Croce Carlo M

Abstract excerpt

The WWOX gene encodes a tumor suppressor spanning the second most common human fragile site, FRA16D. Targeted deletion of the Wwox gene in mice led to an increased incidence of spontaneous and ethyl nitrosourea-induced tumors. In humans, loss of heterozygosity and reduced or loss of WWOX expressi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17575124
DOI: 10.1158/0008-5472.CAN-07-1081
PMCID: PMC2621009

Genes

WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17575124-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo.PMID 17575124Read ↗

Targeted deletion of Wwox reveals a tumor suppressor function.Semantic proximity Read ↗

WWOX: a fragile tumor suppressor.Semantic proximity Read ↗

WWOX in biological control and tumorigenesisSemantic proximity Read ↗

Wwox inactivation enhances mammary tumorigenesis.Semantic proximity Read ↗

Molecular Functions of WWOX Potentially Involved in Cancer DevelopmentSemantic proximity Read ↗

Alteration of WWOX in human cancer: a clinical view.Semantic proximity Read ↗

Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma.Semantic proximity Read ↗

Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene.Semantic proximity Read ↗

FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila.Semantic proximity Read ↗

WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.Semantic proximity Read ↗

The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis.Semantic proximity Read ↗

Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer.Semantic proximity Read ↗

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