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Article

Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice.

Carcinogenesis - 1 Jul 2006

Fong Louise Y Y, Jiang Yubao, Farber John L

Abstract excerpt

Upper aerodigestive tract (UADT) cancer, including oral and esophageal cancer, is an important cause of cancer deaths worldwide. Patients with UADT cancer are frequently zinc deficient (ZD) and show a loss of function of the pivotal tumor suppressor gene p53. The present study examined whether zinc deficiency in collaboration with p53 insufficiency (p53+/-) promotes lingual and esophageal tumorigenesis in mice...

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PMID: 16543248
DOI: 10.1093/carcin/bgl012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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