Article
High susceptibility of p53(+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele.
Cancer research - 1 Sept 1998
Ozaki K, Sukata T, Yamamoto S, Uwagawa S, Seki T, Kawasaki H, Yoshitake A, Wanibuchi H, Koide A, Mori Y, Fukushima S
Abstract excerpt
The loss of p53 functions is considered to compromise the growth-suppression machinery of the cell and facilitate neoplastic change. In humans, genetic alteration in the p53 gene is one of the most frequently observed molecular changes in tumors, including urinary bladder carcinomas. We have inve...
Topics
- Alleles
- Animals
- Butylhydroxybutylnitrosamine
- Carcinogens
- Disease Susceptibility
- Genes, p53
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mutation
- Urinary Bladder Neoplasms