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Article

Leukemogenic Ptpn11 allele causes defective erythropoiesis in mice.

PloS one - 1 Jan 2014

Usenko Tatiana, Chan Gordon, Torlakovic Emina, Klingmüller Ursula, Neel Benjamin G

Abstract excerpt

Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2), encoded by PTPN11, regulates signaling networks and cell fate in many tissues. Expression of oncogenic PTPN11 in the hematopoietic compartment causes myeloproliferative neoplasm (MPN) in humans and mice. However, the stage-specific effect(s) of mutant Ptpn11 on erythroid development have remained unknown. We found that expression of an activated,...

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Source

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Identifiers

PMID: 25289670
DOI: 10.1371/journal.pone.0109682
PMCID: PMC4188809

Genes

PTPN11
EPO
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Leukemogenic Ptpn11 allele causes defective erythropoiesis in mice.PMID 25289670Read ↗

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