Kit-activating mutations in AML: lessons from PU.1-induced murine erythroleukemia.

Abstract excerpt

In concert with its ligand, the stem cell factor (SCF), the receptor tyrosine kinase c-Kit acts as a key signaling molecule for a number of cell types, including hematopoietic stem cells, mast cells, melanocytes and germ cells. Gain-of-function mutations in c-Kit have been described in a number o...

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