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Article

Genetic variation in soluble epoxide hydrolase: association with outcome after aneurysmal subarachnoid hemorrhage.

Journal of neurosurgery - 1 Dec 2014

Martini Ross P, Ward Jonathan, Siler Dominic A, Eastman Jamie M, Nelson Jonathan W, Borkar Rohan N, Alkayed Nabil J, Dogan Aclan, Cetas Justin S

Abstract excerpt

OBJECT: Patients with aneurysmal subarachnoid hemorrhage (SAH) are at high risk for delayed cerebral ischemia (DCI) and stroke. Epoxyeicosatrienoic acids (EETs) play an important role in cerebral blood flow regulation and neuroprotection after brain injury. Polymorphisms in the gene for the enzyme soluble epoxide hydrolase (sEH), which inactivates EETs, are associated with ischemic stroke risk and neuronal...

Topics

Adult
Aged
Epoxide Hydrolases
Female
Gene Expression Regulation, Enzymologic
Genetic Predisposition to Disease
Genetic Variation
Humans
Logistic Models
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Multivariate Analysis

Point Mutation

Polymorphism, Genetic

Risk Factors

Stroke

Subarachnoid Hemorrhage

Treatment Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 25216066
DOI: 10.3171/2014.7.JNS131990
PMCID: PMC4370510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25216066-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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