Article
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.
Nature genetics - 1 May 2008
Monti Jan, Fischer Judith, Paskas Svetlana, Heinig Matthias, Schulz Herbert, Gösele Claudia, Heuser Arnd, Fischer Robert, Schmidt Cosima, Schirdewan Alexander, Gross Volkmar, Hummel Oliver, Maatz Henrike, Patone Giannino, Saar Kathrin, Vingron Martin, Weldon Steven M, Lindpaintner Klaus, Hammock Bruce D, Rohde Klaus, Dietz Rainer, Cook Stuart A, Schunck Wolf-Hagen, Luft Friedrich C, Hubner Norbert
Abstract excerpt
We aimed to identify genetic variants associated with heart failure by using a rat model of the human disease. We performed invasive cardiac hemodynamic measurements in F2 crosses between spontaneously hypertensive heart failure (SHHF) rats and reference strains. We combined linkage analyses with genome-wide expression profiling and identified Ephx2 as a heart failure susceptibility gene in SHHF rats....
Topics
- Animals
- Chromosome Mapping
- Disease Models, Animal
- Epoxide Hydrolases
- Gene Expression Profiling
- Genetic Linkage
- Genetic Predisposition to Disease
- Heart Failure