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Article

Genetically reduced soluble epoxide hydrolase activity and risk of stroke and other cardiovascular disease.

Stroke - 1 Jan 2010

Lee Julie, Dahl Morten, Grande Peer, Tybjaerg-Hansen Anne, Nordestgaard Børge G

Abstract excerpt

BACKGROUND AND PURPOSE: The development of stroke has been linked to lowered levels of epoxyeicosatrienoic acids in the cerebral microvasculature. These substances are metabolized by the enzyme-soluble epoxide hydrolase encoded by the EPHX2 gene. We tested whether genetically reduced soluble epoxide hydrolase activity is associated with risk of ischemic stroke, myocardial infarction, and ischemic heart disease....

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Source

Identifiers

PMID: 19940276
DOI: 10.1161/STROKEAHA.109.567768

Genes

EPHX2

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