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Article

WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2008

Kawasaki Takako, Ohnishi Mutsuko, Suemoto Yuko, Kirkner Gregory J, Liu Zhiqian, Yamamoto Hiroyuki, Loda Massimo, Fuchs Charles S, Ogino Shuji

Abstract excerpt

Werner syndrome is a premature aging syndrome characterized by early onset of cancer and abnormal cellular metabolism of glycosaminoglycan. The WRN helicase plays an important role in the maintenance of telomere function. WRN promoter methylation and gene silencing are common in colorectal cancer with the CpG island methylator phenotype (CIMP), which is associated with microsatellite instability (MSI) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18084250
DOI: 10.1038/modpathol.3800996

Genes

WRN
BRAF
CRABP1
IGF2
KRAS
MLH1
NEUROG1
RUNX3
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer.PMID 18084250Read ↗

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