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Article

MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer.

Carcinogenesis - 1 Sept 2007

Ogino Shuji, Hazra Aditi, Tranah Gregory J, Kirkner Gregory J, Kawasaki Takako, Nosho Katsuhiko, Ohnishi Mutsuko, Suemoto Yuko, Meyerhardt Jeffrey A, Hunter David J, Fuchs Charles S

Abstract excerpt

O-6-methylguanine-DNA methyltransferase (MGMT) repairs inappropriately methylated guanine residues in DNA. MGMT promoter methylation and gene silencing are common events in colorectal cancer, and may or may not co-exist with the CpG island methylator phenotype (CIMP). To date, no study has examined the relationship between MGMT promoter methylation and common MGMT single nucleotide polymorphisms (SNPs), which...

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Topics

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Share to Chromosomes, Human, Pair 18
Share to DNA Modification Methylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to DNA Repair Enzymes

Share to Gene Silencing

Share to Germ-Line Mutation

Share to Loss of Heterozygosity

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 17621591
DOI: 10.1093/carcin/bgm160

Genes

MGMT
BRAF
KRAS
CRABP1
IGF2
MLH1
NEUROG1
RUNX3
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer.PMID 17621591Read ↗

MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa.Semantic proximity Read ↗

Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer.Semantic proximity Read ↗

Detection of MGMT promoter methylation in normal individuals is strongly associated with the T allele of the rs16906252 MGMT promoter single nucleotide polymorphism.Semantic proximity Read ↗

SNP rs16906252C>T Is an Expression and Methylation Quantitative Trait Locus Associated with an Increased Risk of Developing MGMT-Methylated Colorectal Cancer.Semantic proximity Read ↗

O <sup>6</sup> -methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitionsSemantic proximity Read ↗

Genetic and epigenetic landscape of O6-methylguanine-DNA methyltransferase (MGMT): implications for DNA repair and cancer therapeuticsSemantic proximity Read ↗

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Methylation of MGMT and ADAMTS14 in normal colon mucosa: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans.Semantic proximity Read ↗

WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer.Semantic proximity Read ↗

MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of eventsSemantic proximity Read ↗

Integrated Analysis of Somatic DNA Variants and DNA Methylation of Tumor Suppressor Genes in Colorectal CancerSemantic proximity Read ↗

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