Article
Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.
Genes, brain, and behavior - 1 Jun 2008
Hahn M K, Blackford J U, Haman K, Mazei-Robison M, English B A, Prasad H C, Steele A, Hazelwood L, Fentress H M, Myers R, Blakely R D, Sanders-Bush E, Shelton R
Abstract excerpt
Unipolar major depressive disorder (MDD) is a prevalent, disabling condition with multiple genetic and environmental factors impacting disease risk. The diagnosis of MDD relies on a cumulative measure derived from multiple trait dimensions and alone is limited in elucidating MDD genetic determinants. We and others have proposed that MDD may be better dissected using paradigms that assess how specific genes...
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